Phenol → 1,3-dihydro-1-(propyl-4-pyridinylamino)-2H-indol-2-one

HRID 53943

反応式

HRID 53943 の反応式
[CH2:1]([NH:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][C:6]1=[O:14])[CH2:2][CH3:3].C1(O)C=CC=CC=1.Cl.Br[C:24]1[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=1.[OH-].[Na+]>>[CH2:1]([N:4]([C:24]1[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=1)[N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][C:6]1=[O:14])[CH2:2][CH3:3]

参加物

5

反応物 4

HCID 996PhenolHCID 14798Sodium HydroxideHCID 881004-Bromopyridinium chlorideHCID 157036281-(Propylamino)-oxindole

生成物 1

HCID 149942611,3-dihydro-1-(propyl-4-pyridinylamino)-2H-indol-2-one収率 14.4%

実験手順

To a stirred solution of 1,3-dihydro-1-(propylamino)-2H-indol-2-one (10.4 g) and phenol (30.8 g), preheated to 150° C. under nitrogen, was added 4-bromopyridine hydrochloride (11.04 g) over 5 min. Heating was continued for 7 hours at which time the reaction mixture was cooled to room temperature and made basic by slow addition of dilute aqueous sodium hydroxide. The product was extracted four times with ethyl acetate and the combined organic layers back-extracted with dilute aqueous sodium hydroxide, washed with brine, and dried (K2CO3). Filtration and concentration gave the crude product. Purification via flash column chromatography (silica gel, EtOAc), preparative high performance liquid chromatography (HPLC) (silica gel, EtOAc→2% Et3N/0-7% MeOH/EtOAc), and a third column (alumina, EtOAc) followed. Recrystallization from ethyl acetate-pentane afforded 2.10 g (14%) of 1,3-dihydro- 1 -(propyl-4-pyridinylamino)-2H-indol-2-one, as a solid, m.p. 140°-143° C.

後処理

  1. custompreheated to 150° C. under nitrogen
  2. temperatureHeating
  3. extractionThe product was extracted four times with ethyl acetate
  4. extractionthe combined organic layers back-extracted with dilute aqueous sodium hydroxide
  5. washwashed with brine
  6. dry with materialdried (K2CO3)
  7. filtrationFiltration and concentration
  8. customgave the crude product
  9. customPurification via flash column chromatography (silica gel, EtOAc), preparative high performance liquid chromatography (HPLC) (silica gel, EtOAc→2% Et3N/0-7% MeOH/EtOAc)
  10. customRecrystallization from ethyl acetate-pentane

出典と根拠

ORDレコード
ord-d182eef1000647d1abed50508d3c5427
出典データセット
uspto-grants-1997_04
特許番号
US05621116

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