Water → 1-Phenylbut-3-en-1-ol

HRID 539496

反応式

HRID 539496 の反応式
[C:1]1([CH2:7][CH2:8][C:9](=O)[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([Sn](CC=C)(CC=C)CC=C)C=C.[OH2:25]>[Sc]>[C:1]1([CH:7]([OH:25])[CH2:8][CH:9]=[CH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 17355Benzyl acetoneHCID 81878Tetrallylstannane

生成物 1

HCID 2201191-Phenylbut-3-en-1-ol収率 98%

試薬・触媒・溶媒 1

HCID 23952Scandium触媒

実験手順

Water (0.25 ml) was added to this silica gel supporting scandium (75 mg), and while stirring, 4-phenyl-2-butanone (0.25 mmol) and tetraallyltin (0.125 mmol) were continuously added. The mixture was stirred at 40° C. for 24 hours. The mixture was returned to room temperature, and then was extracted four times by a decantation method using hexane. The solvent was distilled off under reduced pressure, and then the residue was purified by silica gel thin layer chromatography, to obtain the target product, 1-phenyl-3-buten-1-ol. Yield 98%.

後処理

  1. stirringThe mixture was stirred at 40° C. for 24 hours
  2. customwas returned to room temperature
  3. extractionwas extracted four times by a decantation method
  4. distillationThe solvent was distilled off under reduced pressure
  5. customthe residue was purified by silica gel thin layer chromatography

出典と根拠

ORDレコード
ord-0b14e358b30946cfa6c18940663f3b8b
出典データセット
uspto-grants-2014_10
特許番号
US08871668B2

関連ノート

読み込み中…