反応式
[SH:1][CH2:2][C@H:3]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]([C:13]([OH:15])=[O:14])[NH:5][C:4]1=[O:16].[C:17](Cl)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([S:1][CH2:2][C@H:3]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]([C:13]([OH:15])=[O:14])[NH:5][C:4]1=[O:16])(=[O:19])[CH3:18]参加物
4
実験手順
Trans 3-mercaptomethyl-2-oxo-1-azacyclodecane-10-carboxylic acid (0.75 g, 3.06 mmol) is dissolved in pyridine (20 mL). Acetyl chloride (0.26 g, 3.37 mmol) is added, and the reaction is stirred at room temperature overnight. The reaction is quenched by cooling to 0° C., adding concentrated hydrochloric acid (20 mL), diluting with water, and extracting several times with ethyl acetate. The combined organic layers are dried (MgSO4), and the solvent is evaporated to give trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecane-10-carboxylic acid, MS:M+1=288.
後処理
- customThe reaction is quenched
- temperatureby cooling to 0° C.
- additionadding concentrated hydrochloric acid (20 mL)
- additiondiluting with water
- extractionextracting several times with ethyl acetate
- dry with materialThe combined organic layers are dried (MgSO4)
- customthe solvent is evaporated
出典と根拠
- ORDレコード
- ord-0675e965fa4340e2acbd5041468c8136
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05244889
関連ノート
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