Pyridine → (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate
反応式
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:13]1[CH:17]=[CH:16][S:15][CH:14]=1)[C:10](O)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].N1C=CC=CC=1.N1C(F)=NC(F)=NC=1[F:26]>C(Cl)Cl>[F:26][C:10](=[O:11])[C@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[C:13]1[CH:17]=[CH:16][S:15][CH:14]=1参加物
5
反応条件
- 温度
- -10 °C
実験手順
To (R)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid in CH2Cl2 cooled to −10° C. was added pyridine and cyanuric fluoride. The solution was stirred for 1 hour at −10° C., quenched with ice and extracted with CH2Cl2 and ice cold water, dried (Na2SO4), filtered and evaporated to give (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate.
後処理
- customquenched with ice
- extractionextracted with CH2Cl2 and ice cold water
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-3012d4375c3c421ba803fd302eede819
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871757B2
反応ノート
読み込み中…