Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 539671

反応式

HRID 539671 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86680852HCID 86680852、化合物

生成物 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-cc4be7e183604fe9ba2a4ce2aab13dc7
出典データセット
uspto-grants-2014_10
特許番号
US08871766B2

関連ノート

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