Water → 5-methyl-3-(pyridin-4-yl)-1H-pyrazole-4-carboxylic acid
反応式
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([O:15]CC)=[O:14].[OH-].[Na+].O>C(O)C>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][N:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]([OH:15])=[O:14]参加物
5
実験手順
To a solution of ethyl 5-methyl-3-(pyridin-4-yl)-1H-pyrazole-4-carboxylate (3.1 g) in ethanol (20 mL) were added sodium hydroxide (8.0 g) and water (10 mL), and the mixture was heated under reflux overnight. The solvent was evaporated under reduced pressure, the pH of the mixture was adjusted to 5 with 2 N hydrochloric acid, and mixture was concentrated under reduced pressure. The obtained solid was collected by filtration and washed with water to give the title compound (2.4 g).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux overnight
- customThe solvent was evaporated under reduced pressure
- concentrationwas concentrated under reduced pressure
- filtrationThe obtained solid was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-86226a465c304d5a8724097833627826
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871766B2
反応ノート
読み込み中…