6-Methoxypyridazin-3-amine → 6-Methoxy-2-(4-methyl-3-nitrophenyl)imidazo[1,2-b]pyridazine

HRID 539731

反応式

HRID 539731 の反応式
[CH3:1][O:2][C:3]1[N:8]=[N:7][C:6]([NH2:9])=[CH:5][CH:4]=1.Br[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([N+:21]([O-:23])=[O:22])[CH:15]=1)=O>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([N+:21]([O-:23])=[O:22])[CH:15]=3)[N:9]=2)[N:8]=1

参加物

4

反応物 2

HCID 816736-Methoxypyridazin-3-amineHCID 38004222-Bromo-1-(4-methyl-3-nitrophenyl)ethan-1-one

生成物 1

HCID 680891556-Methoxy-2-(4-methyl-3-nitrophenyl)imidazo[1,2-b]pyridazine収率 85.2%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A stirred solution of 6-methoxypyridazin-3-amine (Apollo Scientific, 0.750 g, 5.99 mmol) and 2-bromo-1-(4-methyl-3-nitrophenyl)ethanone (1.54 g, 5.99 mmol) in acetonitrile (20 mL) is heated at 80° C. for 16 hours. The reaction mixture is concentrated to dryness and purified via chromatography (hexanes to EtOAc) to afford the title compound (1.45 g, 85%) as a light yellow solid: Rf 0.45 (1:1 EtOAc:hexanes); LCMS (m/z)=285.4 [M+H]+, tR=7.47 min. (10 min run)

後処理

  1. concentrationThe reaction mixture is concentrated to dryness
  2. custompurified via chromatography (hexanes to EtOAc)

出典と根拠

ORDレコード
ord-0bd679a3722445f3b5d6d8b99bb02dc5
出典データセット
uspto-grants-2014_10
特許番号
US08871767B2

関連ノート

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