Potassium Carbonate → N-(4-fluorobenzyl)-5-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline

HRID 539734ノート

反応式

HRID 539734 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2=[N:9][C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH3:19])=[C:16]([CH:18]=3)[NH2:17])=[CH:11][N:5]2[N:4]=1.C([O-])([O-])=O.[K+].[K+].[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1>C(#N)C>[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH:17][C:16]2[CH:18]=[C:12]([C:10]3[N:9]=[C:6]4[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[N:4][N:5]4[CH:11]=3)[CH:13]=[CH:14][C:15]=2[CH3:19])=[CH:29][CH:28]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 680214-Fluorobenzyl bromideHCID 529038205-(6-Methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline

生成物 1

HCID 57406703N-(4-fluorobenzyl)-5-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline収率 34.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

An 8 mL vial is charged with 5-(6-methoxyimidazo[2,1-f]pyridazin-2-yl)-2-methyl-aniline (20.3 mg, 0.08 mmol) in acetonitrile (0.5 mL), K2CO3 (13 mg) and 4-fluorobenzyl bromide (19 mg, 0.1 mmol). The mixture is stirred for 30 min then filtered, and the filtrate is added into water (10 mL). Solids precipitated and are collected by filtration to give the title compound (10 mg, 34% yield) (compound same as Example 102). LCMS m/z=363.3 [M+H]+, tR=2.57 min.

後処理

  1. filtrationthen filtered
  2. additionthe filtrate is added into water (10 mL)
  3. customSolids precipitated
  4. filtrationare collected by filtration

出典と根拠

ORDレコード
ord-c7136958642448089aea0666db0ba728
出典データセット
uspto-grants-2014_10
特許番号
US08871767B2

反応ノート

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