4-Nitrophenyl methyl sulfide → 4-(Methylthio)aniline

HRID 539939

反応式

HRID 539939 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][CH:4]=1.[H][H]>[Ni].CO>[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 961094-Nitrophenyl methyl sulfideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 660384-(Methylthio)aniline収率 92.7%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A suspension of 1-(methylsulfanyl)-4-nitrobenzene (10.5 g, 0.062 mol) and Raney nickel (5 g) in methanol (250 ml) was hydrogenated in a round flask equipped with a balloon filled with hydrogen at room temperature for 16 hours. The resulting mixture was filtered and concentrated in vacuo to afford 8.0 g of 4-(methylsulfanyl)aniline as colorless oil.

後処理

  1. customwas hydrogenated in a round flask
  2. customequipped with a balloon
  3. filtrationThe resulting mixture was filtered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2fca2c1116f94fabaf60c743e89bd88f
出典データセット
uspto-grants-2014_10
特許番号
US08871756B2

関連ノート

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