Methanol → 6-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

HRID 539982ノート

反応式

HRID 539982 の反応式
[CH2:1]([N:8]1[CH2:15][CH:14]([N+:16]([O-])=O)[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+].CO>[Fe].O>[CH2:1]([N:8]1[CH2:15][CH:14]([NH2:16])[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 712547596-Benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane

生成物 1

HCID 712545836-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

The mixture of 6-benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane (2 g, 8.1 mmol), iron powder (2.3 g, 40.5 mmol), ammonium chloride (4.3 g, 81 mmol), methanol (40 mL) and 8 mL of water was heated with stirring for 2 hours at 80° C. The reaction mixture was filtered by a pad of celite. The filtrate was concentrated under reduced pressure, and the residue was used for next step without further purification.

後処理

  1. temperaturewas heated
  2. filtrationThe reaction mixture was filtered by a pad of celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe residue was used for next step without further purification

出典と根拠

ORDレコード
ord-b79e12d3f2d847fa9d2aefa188457128
出典データセット
uspto-grants-2014_10
特許番号
US08871756B2

反応ノート

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