Hydrochloric Acid → HCID 71255323、化合物

HRID 540342ノート

反応式

HRID 540342 の反応式
CC1(C)[N:6](C(OC(C)(C)C)=O)[C@@H:5]([CH2:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[C:18]([N:26]3[CH2:32][CH2:31][CH2:30][C:29]4[CH:33]=[CH:34][CH:35]=[CH:36][C:28]=4[CH2:27]3)[CH:17]=2)[CH2:4][O:3]1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[NH2:6][C@@H:5]([CH2:14][CH2:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[C:18]([N:26]2[CH2:32][CH2:31][CH2:30][C:29]3[CH:33]=[CH:34][CH:35]=[CH:36][C:28]=3[CH2:27]2)[CH:17]=1)[CH2:4][OH:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 86691447HCID 86691447、化合物

生成物 1

HCID 71255323HCID 71255323、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To the solution of tert-butyl (4S)-2,2-dimethyl-4-{2-[2-(1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)quinolin-4-yl]ethyl}-1,3-oxazolidine-3-carboxylate (340 mg, 0.68 mmol) in ethyl acetate was introduced hydrochloric acid gas for 30 minutes. After being stirred at room temperature overnight, the reaction was poured into ice-water then neutralized with saturated sodium carbonate. The organic layer was separated, dried over sodium sulfate, and then concentrated in vacuo to give the product. It was used in next step without further purification. MS obsd. (ESI+) [(M+H)+] 362.

後処理

  1. customThe organic layer was separated
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated in vacuo
  4. customto give the product
  5. customIt was used in next step without further purification

出典と根拠

ORDレコード
ord-43a9d792fb8b4495b6c9566e355f4086
出典データセット
uspto-grants-2014_10
特許番号
US08871756B2

反応ノート

読み込み中…