Trifluoroacetic acid → 3-Pentoxy-3-phenylazetidine trifluoroacetate

HRID 540375ノート

反応式

HRID 540375 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([O:13][C:14]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]1)[CH2:9][CH2:10][CH2:11][CH3:12]>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([O:13][C:14]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:17][NH:16][CH2:15]1)[CH2:9][CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 669885513-Pentoxy-3-phenyl-1-(tert-butoxycarbonyl)azetidine

生成物 1

HCID 669889253-Pentoxy-3-phenylazetidine trifluoroacetate収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5.5 ml of trifluoroacetic acid are added to a solution containing 3.34 g (10 mmol) of 3-pentoxy-3-phenyl-1-(tert-butoxycarbonyl)azetidine dissolved in 10 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 2 hours 30 min and then concentrated. The crude product obtained is purified by silica gel chromatography (eluent 90/10 dichloromethane/methanol). 3.5 g in the form of a pale yellow oil are obtained with a yield of 100%.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-6926ba8cc6ed4f37a899bfd8a31ed63a
出典データセット
uspto-grants-2014_10
特許番号
US08871187B2

反応ノート

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