3-(1-Benzyl-1H-1,2,3-triazol-4-yl)propanoic acid → HCID 178525362、化合物
反応式
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1参加物
5
反応条件
- 温度
- 60 °C
実験手順
39 mg of palladium-on-charcoal at 10% are added to a solution containing 390 mg (1.7 mmol) of 3-(1-benzyl-1H[1,2,3]triazol-4-yl)propanoic acid in 3 ml of methanol. The reaction mixture is placed under 10 bar of hydrogen pressure and stirred at 60° C. for 16 hours. After filtration through celite, the solvents are evaporated off and the residue is purified by silica gel chromatography (eluent 95/5 dichloro-methane/methanol). 159.8 mg of 3-(1H[1,2,3]triazol-4-yl)propanoic acid are obtained in the form of a white powder with a yield of 67%.
後処理
- filtrationAfter filtration through celite
- customthe solvents are evaporated off
- customthe residue is purified by silica gel chromatography (eluent 95/5 dichloro-methane/methanol)
出典と根拠
- ORDレコード
- ord-a83c3de4790542fdabc54705a81b2f89
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871187B2
反応ノート
読み込み中…