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N-Methylmaleimide → 4-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylmaleimide | HCID 70261 | — |
| 反応物 | Pipecolic acid, (+)- | HCID 736316 | — |
| 反応物 | (E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenal | HCID 86676729 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione | HCID 53492367 | — |
反応手順
A mixture of 235 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 133 mg of D-pipecolinic acid, 115 mg of N-methylmaleimide and 30 ml of MeCN is heated at the boil for 2 h. The volatile components are removed under reduced pressure and the residue is purified by column chromatography (silica gel, MeOH:DCM=97:3). In this manner, 2 pure fractions are isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08871798B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-3857c9eaa0c34ea8a260062be61b4bfb |
| 出典メモ | uspto-grants-2014_10 |