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Potassium Hydroxide → (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Benzyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate | HCID 10860587 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane | HCID 9861019 | 99.5% |
反応手順
A solution of 11.4 g of 3(S)-(benzyloxyformamido)-1-chloro-4-phenyl-2(S)-butanol in 300 ml of ethanol containing 2.24 g of potassium hydroxide was left to stand for 15 minutes. The solvent was removed by evaporation and the residue was partitioned between water and dichloromethane. Working-up gave 10.1 g of crude 3(S)-(benzyloxyformamido)-1,2(S)-epoxy-4-phenylbutane as an off-white solid which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620987 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-6ad909a6484b4f0ba9bd467981f97cca |
| 出典メモ | uspto-grants-1997_04 |