Morpholine → 2-Bromo-1-(morpholin-4-yl)ethan-1-one

HRID 540840ノート

反応式

HRID 540840 の反応式
[Br:1][CH2:2][C:3](Br)=[O:4].[NH:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1>ClCCl>[Br:1][CH2:2][C:3]([N:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)=[O:4]

参加物

4

反応物 2

HCID 8083MorpholineHCID 61147Bromoacetyl bromide

生成物 1

HCID 139968762-Bromo-1-(morpholin-4-yl)ethan-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

反応条件

温度
-25 °C

実験手順

A solution of bromoacetyl bromide (3.0 mL, 0.034 mol) in dichloromethane (240 mL) was cooled to −25° C. A solution of morpholine (9.0 mL, 0.10 mol) in dichloromethane (20 mL) was slowly added over a period of one hour. After the addition was complete, the reaction was stirred at −25° C. for 15 minutes and allowed to warm to ambient temperature. Dichloromethane was added, and the resulting solution was washed with water, 1N aqueous hydrogen chloride, and brine; dried over magnesium sulfate; filtered; and concentrated under reduced pressure to provide 4-(2-bromoacetyl)morpholine as a colorless oil.

後処理

  1. additionAfter the addition
  2. temperatureto warm to ambient temperature
  3. washthe resulting solution was washed with water, 1N aqueous hydrogen chloride, and brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationand concentrated under reduced pressure

出典と根拠

ORDレコード
ord-55d596370a7c48f69f499e21e2284326
出典データセット
uspto-grants-2014_10
特許番号
US08871782B2

反応ノート

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