Sodium Azide → 2-(Azidomethyl)-1,3-difluorobenzene

HRID 541030ノート

反応式

HRID 541030 の反応式
[CH:1]1[CH:2]=[C:3]([F:17])[C:4]([CH2:8][N:9]2[N:13]=[N:12]C(C(N)=O)=C2)=[C:5]([F:7])[CH:6]=1.FC1C=CC=C(F)C=1CCl.[N-]=[N+]=[N-].[Na+]>CS(C)=O>[F:7][C:5]1[CH:6]=[CH:1][CH:2]=[C:3]([F:17])[C:4]=1[CH2:8][N:9]=[N+:13]=[N-:12]

参加物

5

反応物 3

HCID 33557Sodium AzideHCID 129228RufinamideHCID 5815702,6-Difluorobenzyl chloride

生成物 1

HCID 108883232-(Azidomethyl)-1,3-difluorobenzene

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The process comprises the preparation of Rufinamide by reacting 2,6-difluorobenzyl chloride and sodium azide in the presence of DMSO to obtain 2,6-difluoro benzyl azide, which is then treated with propiolic acid to give carboxylic acid intermediate which on further reaction with thionyl chloride to give corresponding acyl chloride. The acyl chloride intermediate is further reacted with methanolic ammonia to yield Rufinamide.

出典と根拠

ORDレコード
ord-e0f8f2ef8757448e9280c2a58b32364a
出典データセット
uspto-grants-2014_10
特許番号
US08871945B2

反応ノート

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