Einecs 211-027-4 → 3-Hydroxy-indeno[1,2-b]pyridin-5-one

HRID 541151ノート

反応式

HRID 541151 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1.[Cl-].[NH+]1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1

参加物

4

反応物 2

HCID 69401Einecs 211-027-4HCID 594930653-Methoxy-indeno[1,2-b]pyridin-5-one

生成物 1

HCID 594925083-Hydroxy-indeno[1,2-b]pyridin-5-one収率 10.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
180 °C

実験手順

Under an argon atmosphere, 3-methoxy-indeno[1,2-b]pyridin-5-one (0.545 g) and pyridinium chloride (5.89 g) were mixed with pyridine (1.0 ml). The reaction mixture was stirred with heating at 180° C. for 30 min while evaporating pyridine, and further stirred with heating at 200° C. for 4 hr. The mixture was cooled to room temperature, water was added and the mixture was stirred for 30 min. This slurry was filtered, and the obtained solid was dried under reduced pressure to give the title compound (0.054 g). The obtained solid was used for the next reaction without further purification.

後処理

  1. customwhile evaporating pyridine
  2. stirringfurther stirred
  3. temperaturewith heating at 200° C. for 4 hr
  4. temperatureThe mixture was cooled to room temperature
  5. additionwater was added
  6. stirringthe mixture was stirred for 30 min
  7. filtrationThis slurry was filtered
  8. customthe obtained solid was dried under reduced pressure

出典と根拠

ORDレコード
ord-f428e289ddec4cc284fdab8226f447db
出典データセット
uspto-grants-2014_10
特許番号
US08871934B2

反応ノート

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