Hydrazine hydrate (1:1) → Oxolane-3-carbohydrazide

HRID 541208

反応式

HRID 541208 の反応式
[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([O:8]C)=O)[CH2:2]1.O.[NH2:11][NH2:12]>>[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([NH:11][NH2:12])=[O:8])[CH2:2]1

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 10678263Methyl oxolane-3-carboxylate2 回

生成物 1

HCID 46942244Oxolane-3-carbohydrazide収率 74%

実験手順

Into around-bottom flask, was placed hydrazine hydrate (20 mL). To this was added methyl tetrahydrofuran-3-carboxylate (compound 38.1, 390 mg, 3.00 mmol, 1.00 equiv) dropwise with stirring. The resulting mixture was stirred at 50° C. in an oil bath. After 3 h, the reaction mixture was concentrated and dried under reduced pressure to yield 0.29 g (74%) of the title compound as a colorless oil.

後処理

  1. customInto around-bottom flask, was placed
  2. stirringThe resulting mixture was stirred at 50° C. in an oil bath
  3. concentrationthe reaction mixture was concentrated
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-38f8c1db6fa54ce0ab4ba1364e836a24
出典データセット
uspto-grants-2014_10
特許番号
US08871790B2

関連ノート

読み込み中…