Sodium Hydroxide → 5-Amino-2,4-dimethylbenzoic acid
反応式
[NH2:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([CH3:12])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO.O>[NH2:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([CH3:12])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of methyl 5-amino-2,4-dimethylbenzoate (1.2 g, 6.70 mmol, 1.00 equiv) and sodium hydroxide (1.5 g, 37.50 mmol, 5.60 equiv) in methanol/H2O (20/20 mL) was stirred overnight at 50° C. After cooling to ambient temperature, the organic phase was removed under reduced pressure. The pH of the remaining aqueous layer was adjusted to ˜4-5 with hydrogen chloride (aq., 2 M). The resulting solids were collected by filtration and dried to yield 1.0 g of a yellow solid.
後処理
- temperatureAfter cooling to ambient temperature
- customthe organic phase was removed under reduced pressure
- filtrationThe resulting solids were collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-0fa06acd826542529e735f1df7c041ce
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871790B2
反応ノート
読み込み中…