Hydrazine → (2R)-oxolane-2-carbohydrazide
反応式
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([OH:8])=O.CCN=C=NCCCN(C)C.C1C=CC2N(O)[N:27]=[N:26]C=2C=1.NN>ClCCl>[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([NH:26][NH2:27])=[O:8]参加物
6
反応条件
- 温度
- 25 °C
実験手順
A mixture of (R)-tetrahydrofuran-2-carboxylic acid (5.00 g, 43.1 mmol, 1.00 equiv), EDCI (12.4 g, 64.6 mmol, 1.50 equiv) and HOBt (8.70 g, 64.4 mmol, 1.50 equiv) in dichloromethane (100 mL) was stirred for 30 min at 25° C. To the mixture was then added hydrazine (2.00 g, 62.4 mmol, 1.50 equiv) dropwise. The resulting mixture was stirred overnight at 25° C. The solids were removed by filtration, and the filtrate was concentrated in vacuo to furnish 25.0 g (crude) of (R)-tetrahydrofuran-2-carbohydrazide as a yellow oil.
後処理
- stirringThe resulting mixture was stirred overnight at 25° C
- customThe solids were removed by filtration
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-bbac68750f9f46808fa79290ea0f7700
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871790B2
反応ノート
読み込み中…