Diethyl Oxalate → Ethyl 2-hydrazinyl-2-oxoacetate

HRID 541252

反応式

HRID 541252 の反応式
[C:1]([O:8]CC)(=O)[C:2]([O:4][CH2:5][CH3:6])=[O:3].O.[NH2:12][NH2:13]>C(O)C>[NH:12]([C:1](=[O:8])[C:2]([O:4][CH2:5][CH3:6])=[O:3])[NH2:13]

参加物

4

反応物 2

HCID 7268Diethyl OxalateHCID 24654Hydrazine hydrate (1:1)

生成物 1

HCID 2786935Ethyl 2-hydrazinyl-2-oxoacetate収率 88.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a round-bottom flask was added a solution of diethyl oxalate (10.0 g, 68.4 mmol, 1.00 equiv) in ethanol (100 mL). Hydrazine hydrate (2.75 g, 85.8 mmol, 1.00 equiv) was added and the resulting mixture was stirred for 3 h at 80° C. After cooling to ambient temperature, the solids were removed via filtration and the filtrate was concentrated in vacuo to yield 8.00 g (80%) of the title compound as a colorless oil.

後処理

  1. temperatureAfter cooling to ambient temperature
  2. customthe solids were removed via filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-9d12edd2be484311be42d75512ec3b4e
出典データセット
uspto-grants-2014_10
特許番号
US08871790B2

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