Hydrazine hydrate (1:1) → 2-(Tetrahydrofuran-2-yl)acetohydrazide

HRID 541260ノート

反応式

HRID 541260 の反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([O:9]CC)=O.[NH2:12][NH2:13].O>C(O)C>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([NH:12][NH2:13])=[O:9]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 551345Ethyl Tetrahydrofuran-2-acetate

生成物 1

HCID 607781292-(Tetrahydrofuran-2-yl)acetohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a round-bottom flask was added a solution of ethyl 2-(tetrahydrofuran-2-yl)acetate (2.00 g, 12.6 mmol, 1.00 equiv) in ethanol (20 mL). NH2NH2.H2O (1.27 g, 25.4 mmol, 2.00 equiv) was added to the reaction. The resulting solution was stirred overnight at 80° C. in an oil bath, then cooled to room temperature and concentrated in vacuo. This resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil.

後処理

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. customThis resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil

出典と根拠

ORDレコード
ord-fd7e36a49ee94c47a871bf7e7cfaa5c4
出典データセット
uspto-grants-2014_10
特許番号
US08871790B2

反応ノート

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