2-(2',3'-Dimethoxyphenyl)-1-furanylethanone → 2-(2',3'-Dimethoxyphenyl)-1-tetrahydrofuranyl ethanol
反応式
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:11][C:12]([C:14]1[O:15][CH:16]=[CH:17][CH:18]=1)=[O:13].[H][H]>[Pd].CO>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:11][CH:12]([CH:14]1[CH2:18][CH2:17][CH2:16][O:15]1)[OH:13]参加物
5
実験手順
A solution of 450 mg(1.8 mmol) of 2-(2',3'-dimethoxyphenyl)-1-furanylethanone, from Step 2, and 20% palladium on carbon (225 mg) in 75 mL of methanol was shaken under 4 atmospheres of hydrogen until hydrogen uptake ceased. The solution was filtered and concentrated in vacuo to give 320 mg (69% yield) of the title compound as an oily solid. This product was carried on without purification to the next step.
後処理
- filtrationThe solution was filtered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-8c04c4ddd0734cad882f9e5058c66578
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05621133
反応ノート
読み込み中…