methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate → methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate
反応式
[CH3:1][N:2]1[C:6]([N+:7]([O-])=O)=[CH:5][C:4]([C:10]([O:12][CH3:13])=[O:11])=[N:3]1>CO.[Pd]>[NH2:7][C:6]1[N:2]([CH3:1])[N:3]=[C:4]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1参加物
4
実験手順
To a solution of methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate (351.2, 0.48 g, 2.60 mmol) in MeOH (15 ml) under nitrogen was added palladium on carbon (10%, 0.25 g). The flask was further degassed with nitrogen and filled with H2 through a balloon. The mixture was stirred at room temperature for 1.5 hours. After purging the system with nitrogen, the reaction mixture was filtered through a Celite cake and concentrated to give 363 mg (90%) of a white solid. m/z (ES+) 156 (M+H)+.
後処理
- customThe flask was further degassed with nitrogen
- additionfilled with H2 through a balloon
- customAfter purging the system with nitrogen
- filtrationthe reaction mixture was filtered through a Celite cake
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a816c534cab34aa99d425cc78aa7ee08
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871790B2
反応ノート
読み込み中…