HCID 57962249、化合物 → tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamate

HRID 541835ノート

反応式

HRID 541835 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 57962249HCID 57962249、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 57962170tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamate収率 94%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl (3-{[(3-nitrophenyl)acetyl]amino}phenyl)carbamate (0.35 g, 0.94 mmol) in methanol (100 mL) was added 10% palladium on carbon (1:10, Palladium:carbon black, 0.15 g, 0.13 mmol). The reaction was shaken under 60 psi hydrogen gas overnight. The crude mixture was filtered through celite and concentrated under vacuum to give the desired product (0.30 g, 94%). LCMS for C19H23N3O3 (M-tBu+H)+: m/z=286.0.

後処理

  1. filtrationThe crude mixture was filtered through celite
  2. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-270278be8ca946d49928fcfffd8b94e5
出典データセット
uspto-grants-2014_10
特許番号
US08871753B2

反応ノート

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