HCID 57961596、化合物 → tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate

HRID 541842ノート

反応式

HRID 541842 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 57961596HCID 57961596、化合物

生成物 1

HCID 57962008tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate収率 95%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a mixture of tert-butyl {2-[(3-aminophenyl)ethynyl]pyridin-4-yl}carbamate (250 mg, 1.62 mmol) (prepared in Example C12, step A) in methanol (10 mL) was added 10% palladium on carbon (0.30 g, 0.24 mmol). The reaction mixture was hydrogenated at 50 psi overnight. The resultant mixture was filtered and concentrated to provide the desired product (240 mg, 95%) as a white solid. LCMS for C18H24N3O2 (M+H)+: m/z=314.0.

後処理

  1. customwas hydrogenated at 50 psi overnight
  2. filtrationThe resultant mixture was filtered
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-9260dea853494d6cb6f944618256c05a
出典データセット
uspto-grants-2014_10
特許番号
US08871753B2

反応ノート

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