2-(3-Nitrophenoxy)tetrahydro-2H-pyran → HCID 12046288、化合物
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[O:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9]1)([O-])=O>CO.[Pd]>[O:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:8]1[O:7][C:6]1[CH:5]=[C:4]([CH:16]=[CH:15][CH:14]=1)[NH2:1]参加物
4
反応条件
- 温度
- 25 °C
実験手順
A solution of 2-(3-nitrophenoxy)tetrahydro-2H-pyran (1.0 g, 4.5 mmol) in methanol (13 mL) was degassed with nitrogen (3×) and treated with 10% Pd/C (wet Degussa type) (12 mg). The reaction mixture was degassed and stirred under an atmosphere of hydrogen at 25° C. for 2 h. The reaction mixture was filtered to give the desired product (0.87 g, quantitative) as a tan oil. LCMS for C11H16NO2 (M+H)+: m/z=194.0.
後処理
- customThe reaction mixture was degassed
- filtrationThe reaction mixture was filtered
出典と根拠
- ORDレコード
- ord-e0b2a93eb9534ea9a930acff14c00403
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871753B2
反応ノート
読み込み中…