Testosterone → Testosterone chloroformate

HRID 54201

反応式

HRID 54201 の反応式
[CH3:1][C@@:2]12[C@@H:10]([OH:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH2:13][C:14]3[C@@:20]([CH3:21])([C@H:5]1[CH2:4][CH2:3]2)[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=3.[C:22]([Cl:25])(Cl)=[O:23]>O1CCCC1.C1(C)C=CC=CC=1>[CH3:1][C@@:2]12[C@@H:10]([OH:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH2:13][C:14]3[C@@:20]([CH3:21])([C@H:5]1[CH2:4][CH2:3]2)[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=3.[Cl:25][C:22]([O-:23])=[O:11]

参加物

5

反応物 2

HCID 6013TestosteroneHCID 6371Phosgene

生成物 1

HCID 86750721Testosterone chloroformate

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Testosterone chloroformate was prepared as follows. To a solution of testosterone (2 g, 7.0 mmol) dissolved in tetrahydrofuran (50 ml) was added a 1.93M solution of phosgene in toluene (33 ml). The resulting solution was stirred for 4 h at room temperature, concentrated under vacuum, and the resulting residue vacuum dried for approximately 30 minutes (2.88 g).

後処理

  1. concentrationconcentrated under vacuum
  2. customthe resulting residue vacuum dried for approximately 30 minutes (2.88 g)

出典と根拠

ORDレコード
ord-b991a1c982d64672adc38b13b07157e4
出典データセット
uspto-grants-1997_04
特許番号
US05622944

関連ノート

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