Ethyl 4-azido-2,6-bis(trifluoromethyl)-3-pyridinecarboxylate → Ethyl 4-amino-2,6-bis(trifluoromethyl)-3-pyridinecarboxylate
反応式
[N:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:7]=[C:6]([C:14]([F:17])([F:16])[F:15])[C:5]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[N+]=[N-].[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[N:7]=[C:6]([C:14]([F:17])([F:15])[F:16])[C:5]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]参加物
5
実験手順
A mixture of 2.0 g (0.00611 mol) of product of Example 27, 100 mg of 10% Pd-C and 20 ml of ethanol was hydrogenated with 30 lbs. hydrogen pressure for three hours and filtered. The filtrate was concentrated. The residual oil (1.7 g) was triturated with petroleum ether and filtered to give 1.5 g (87%) of product as a white powder; mp 43°-45° C.