1-Carbomethoxy-4-benzylpiperazine → Methyl piperazine-1-carboxylate
反応式
[C:1]([N:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2].[H][H]>C(O)C.[Pd]>[C:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2]参加物
5
実験手順
34.0 g (0.15 mole) of 1-carbomethoxy-4-benzylpiperazine dissolved in 300 ml of ethanol was treated with hydrogen over a palladium catalyst at 40 psi and room-temperature for 24 hours. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was distilled, b.p. 70°-75° C. at 1.5 mmHg to give 16.0 g of 1-carbomethoxypiperazine.
後処理
- customThe catalyst was removed by filtration
- customthe solvent removed under reduced pressure
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-15e9a2f423724c79a6999dbee1549894
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04656175
反応ノート
読み込み中…