反応式
[CH3:1][NH:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1.[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH2:23][C:24](O)=[O:25])=[CH:15]1.S(Cl)([Cl:29])=O.CCOCC>C(Cl)Cl>[ClH:29].[CH3:1][N:2]([C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)[C:24](=[O:25])[CH2:23][C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][CH:15]=1参加物
6
実験手順
Trans-N-methyl-2-(1-pyrrolidinyl)cyclohexanamine (0.368 g) was dissolved in methylene chloride (10 ml) and stirred at room temperature. The acid chloride of 3-indole acetic acid (prepared by the action of thionyl chloride on 3-indole acetic acid, 0.35 g) dissolved in methylene chloride (10 ml) was added and let stand for five hours. Ether was added to rapidly stirred solution until no more precipitate appeared. After further rapid stirring for one hour, the precipitate was filtered and dried in a vacuum oven at 90° C. for one hour and stored in a predried bottle. The product was in the form of a black glassy solid (300 mg).
後処理
- additionwas added
- stirringAfter further rapid stirring for one hour
- filtrationthe precipitate was filtered
- customdried in a vacuum oven at 90° C. for one hour
出典と根拠
- ORDレコード
- ord-cbfb82d7941c46abb4d7a72f6132adf3
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04656182
関連ノート
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