反応式
[N+:1]([C:4]1[CH:5]=[C:6](C=C[CH:30]=1)[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:20][CH:19]=1)=[O:13])=O)([O-:3])=[O:2].[NH2:31]/[C:32](/[CH3:41])=[CH:33]\[C:34]([O:36][CH2:37][CH2:38][S:39][CH3:40])=[O:35].[CH2:42](O)[CH3:43]>>[CH3:42][C:43]1[NH:31][C:32]([CH3:41])=[C:33]([C:34]([O:36][CH2:37][CH2:38][S:39][CH3:40])=[O:35])[CH:9]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:30]=2)[C:11]=1[C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:22][CH:23]=1)=[O:13]参加物
4
反応条件
- 温度
- -5 °C
実験手順
15 g (0.04 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 6.37 g (0.04 moles) of 2-methylthioethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol during 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-methylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in ethanol--at 76° C.-80° C. The yield is 80% of the theoretical yield.
出典と根拠
- ORDレコード
- ord-8aee582f035746cf9380b565fe717282
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04656181
関連ノート
読み込み中…