Isoquinoline → Decahydroisoquinoline

HRID 542254

反応式

HRID 542254 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>[C].[Ru]>[CH2:1]1[CH:10]2[CH:5]([CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:4][CH2:3][NH:2]1

参加物

3

反応物 1

HCID 8405Isoquinoline

生成物 1

HCID 97812Decahydroisoquinoline収率 76%

試薬・触媒・溶媒 1

HCID 178503044HCID 178503044、化合物触媒

実験手順

In an autoclave, 120 g (0.93 mol) of the aforementioned desulfurized isoquinoline 6 g of 5% ruthenium-carbon (Ru/C) catalyst were subjected to hydrogenation at a temperature of 180° C. under a hydrogen pressure of 140 kg/cm2 ·G for 60 hours. The total amount of hydrogen absorbed during the reaction was 4.9 moles and the molar ratio of the absorbed hydrogen to isoquinoline was 5.3. The reaction mixture obtained after separation of the catalyst by filtration was analyzed by gas chromatography. It was found to contain 88% of decahydroisoquinoline. By distilling this reaction mixture, 98 g (76% in yield) of decahydroisoquinoline (197° C. to 210° C. fraction) was obtained. The trans/cis ratio of this decahydroisoquinoline was found to be 6/4.

後処理

  1. customwere subjected to hydrogenation at a temperature of 180° C. under a hydrogen
  2. custom·G for 60 hours
  3. customThe total amount of hydrogen absorbed during the reaction
  4. customThe reaction mixture obtained
  5. customafter separation of the catalyst
  6. filtrationby filtration
  7. distillationBy distilling this reaction mixture

出典と根拠

ORDレコード
ord-a712f8464aa642a5a99a1f420a63e56f
出典データセット
uspto-grants-1987_04
特許番号
US04656279

関連ノート

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