Aniline → Ethyl 3-anilinobut-2-enoate

HRID 542268

反応式

HRID 542268 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([O:10][C:11](=[O:16])[CH2:12][C:13]([CH3:15])=O)[CH3:9].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:8]([O:10][C:11](=[O:16])[CH:12]=[C:13]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:15])[CH3:9]

参加物

5

反応物 3

HCID 6115AnilineHCID 8868Ethyl AcetoacetateHCID 521998p-Toluenesulfonic acid monohydrate

生成物 1

HCID 94928Ethyl 3-anilinobut-2-enoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Aniline (0.20 mol) and ethylacetoacetate (0.20 mol) are mixed in toluene (200 mL) containing 0.04 g of p-toluenesulfonic acid-hydrate and heated at reflux under a water separator for one hour. The toluene is removed under vacuum to afford the ethyl-3-phenylaminobut-2-enoate which can be used as is for the preparation of the ethyl 2-methyl-3-quinolinecarboxylate.

後処理

  1. temperatureheated
  2. temperatureat reflux under a water
  3. customThe toluene is removed under vacuum

出典と根拠

ORDレコード
ord-c2fa03bdf09e4696bdc72a952c4a4034
出典データセット
uspto-grants-1987_04
特許番号
US04656283

関連ノート

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