関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylenediamine | HCID 3301 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 2,6-dichlorobenzenesulfonic Acid | HCID 4051324 | — |
| 生成物 | Clonidine | HCID 2803 | — |
反応手順
2,6-dichlorophenylsulfonic acid (1.0 g, 0.0037 m) was added to ethylenediamine (0.5 g, 0.008 m) in the absence of solvent. The reaction exothermed to 35° C. and was diluted with acetonitrile and heated at 65° C. for 7.25 hr. The reaction was concentrated, treated with sodium hydroxide and extracted with methylene chloride. The organic phase was dried and concentrated to yield 0.5 g of clonidine. The product was identified by spectroscopic methods.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04656291 |
|---|
| 出典データセット | uspto-grants-1987_04 |
|---|
| ORD ID | ord-a6f8964ffc3341fca1c328b0030d7bf8 |
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| 出典メモ | uspto-grants-1987_04 |
|---|
