反应详情

温度

65 °C

2,6-dichlorophenylsulfonic acid (1.0 g, 0.0037 m) was added to ethylenediamine (0.5 g, 0.008 m) in the absence of solvent. The reaction exothermed to 35° C. and was diluted with acetonitrile and heated at 65° C. for 7.25 hr. The reaction was concentrated, treated with sodium hydroxide and extracted with methylene chloride. The organic phase was dried and concentrated to yield 0.5 g of clonidine. The product was identified by spectroscopic methods.

1. customexothermed to 35° C.
2. concentrationThe reaction was concentrated
3. additiontreated with sodium hydroxide
4. extractionextracted with methylene chloride
5. customThe organic phase was dried
6. concentrationconcentrated