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Isoamylamine → n[3(s)-Benzyloxycarbonylamino-2(r)-hydroxy-4-phenylbutyl]n-isoamylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isoamylamine | HCID 7894 | — |
| 反応物 | (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane | HCID 9861019 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | n[3(s)-Benzyloxycarbonylamino-2(r)-hydroxy-4-phenylbutyl]n-isoamylamine | HCID 10430124 | 81% |
反応手順
A solution of N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane (30.1 g, 0.10 mol) and 165 mL isoamylamine in 150 mL of isopropyl alcohol was heated to reflux for 2.5 hours. The solution was cooled to room temperature, concentrated in vacuo and then recrystallized. The product was isolated by filtration and from ethylacetate/hexane to afford 31.7 g (81%) of N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622949 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-e3445cf91de6468cba1bfd93db043cdd |
| 出典メモ | uspto-grants-1997_04 |