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HRID54238

反应详情

EQUATION

反应方程式

HRID 54238 的结构方程式

REACTANTS

反应物

2
结构：CC(C)CCN
HCID7894

3-Methyl-1-butanamine

C5H13N

结构：O=C(N[C@@H](Cc1ccccc1)[C@H]1CO1)OCc1ccccc1
HCID9861019

Phenylmethyl N-[(1S)-1-[(2S)-2-oxiranyl]-2-phenylethyl]carbamate

C18H19NO3

PRODUCTS

生成物

1
结构：CC(C)CCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
HCID10430124

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane (30.1 g, 0.10 mol) and 165 mL isoamylamine in 150 mL of isopropyl alcohol was heated to reflux for 2.5 hours. The solution was cooled to room temperature, concentrated in vacuo and then recrystallized. The product was isolated by filtration and from ethylacetate/hexane to afford 31.7 g (81%) of N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine.

WORKUP

后处理

  1. temperatureto reflux for 2.5 hours
  2. concentrationconcentrated in vacuo
  3. customrecrystallized
  4. customThe product was isolated by filtration and from ethylacetate/hexane