関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Benzenepropanoic acid, 4-nitro-beta-oxo-, ethyl ester | HCID 13281 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Acetic acid, (p-aminobenzoyl)-, ethyl ester (6CI,7CI) | HCID 3045879 | 83.1% |
反応手順
A mixture of 224 g of reduced iron, 13.4 g of ammonium chloride, 1,000 ml of isopropyl alcohol, and 200 ml of water was prepared, and then 237 g of ethyl p-nitrobenzoylacetate was added thereto in small amounts at temperatures ranging between 50° and 70° C. They were reacted at 70° C. for 1 hour and then the reaction solution was filtered. Then, 1,000 ml of water was added to the filtrate and cooled to 5° C., and crystals precipitated were collected by filtration to yield 172 g of yellow ethyl p-aminobenzoylacetate crystals, m.p., 82°-4° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04657848 |
|---|
| 出典データセット | uspto-grants-1987_04 |
|---|
| ORD ID | ord-e2635a4e17704d4890f22ca506076b41 |
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| 出典メモ | uspto-grants-1987_04 |
|---|
