Tris(furan-2-yl)phosphane → 2,4-Diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine

HRID 54255

反応式

[O:1]=[C:2]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[CH:3]=[CH:4][Sn](CCCC)(CCCC)CCCC.[NH2:25][C:26]1[N:31]=[C:30]([NH2:32])[C:29](I)=[C:28]([CH3:34])[N:27]=1.O1C=CC=C1P(C1OC=CC=1)C1OC=CC=1>CN(C)C=O>[NH2:25][C:26]1[N:31]=[C:30]([NH2:32])[C:29]([CH:4]=[CH:3][C:2]([C:18]2[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=2)=[O:1])=[C:28]([CH3:34])[N:27]=1

参加物

実験手順

This compound is prepared in a manner analogous to that of Step E of Example 4, using 2.9 grams of (0.0064 mole) of 1-oxo-1-(4-chlorophenyl)-3-tributylstannyl-2-propene, 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine (prepared in Step B of Example 3), 0.04 gram of tri-2-furylphosphine and 0.04 gram (catalyst) of tris(dibenzylidineacetone)dipalladium(0) in 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine.

後処理

customThis compound is prepared in a manner analogous to that of Step E of Example 4

出典と根拠

ORDレコード: ord-971f2e7a68da453ba8b23abb58bd156e
出典データセット: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05622954

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート