Acetic Anhydride → 6-Acetamido-8-bromo-1,7-naphthyridine
反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Br:12])[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Br:12])[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2)(=[O:15])[CH3:14]参加物
4
実験手順
Suspended in 32 ml of pyridine was 4.84 g of 6-amino-8-bromo-1,7-naphthyridine, followed by an addition of 66 ml of acetic anhydride. The resultant mixture was stirred at room temperature for 4 hours. After the reaction, the reaction mixture was poured in 500 ml of ice water and crystals, which precipitated out, were collected by filtration and then washed thoroughly with water. They were recrystallized from methanol to obtain 5.37 g of 6-acetamido-8-bromo-1,7-naphthyridine as colorless needle-like crystals (yield: 93.4%).
後処理
- customAfter the reaction
- customcrystals, which precipitated out
- filtrationwere collected by filtration
- washwashed thoroughly with water
- customThey were recrystallized from methanol
出典と根拠
- ORDレコード
- ord-44421d17edfe4323b8b4172b6c1cf6ce
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04659710
反応ノート
読み込み中…