Hydrogen Bromide → 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

HRID 542727ノート

反応式

HRID 542727 の反応式
C([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19]C)[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=O)C.[BrH:21]>>[BrH:21].[OH:19][C:12]1[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:14][C:7]2[CH2:6][CH2:5][NH:4][CH2:10][CH2:9][C:8]=2[CH:11]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 138533553-Acetyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

生成物 1

HCID 212428778-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

実験手順

3-Acetyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (1 g, 0.003 m) in 48% hydrobromic acid (15 ml) was heated to reflux for 16 hours and concentrated in vacuo. The residue was triturated with acetone and recrystallized from methanol-water to give 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrobromide, m.p. 300° (decomp.).

後処理

  1. temperatureto reflux for 16 hours
  2. concentrationconcentrated in vacuo
  3. customThe residue was triturated with acetone
  4. customrecrystallized from methanol-water

出典と根拠

ORDレコード
ord-e7429b7028df46c5a1138f52a5e31fb0
出典データセット
uspto-grants-1987_04
特許番号
US04659706

反応ノート

読み込み中…