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Dimethyl Sulfate → 1-Bromo-3-methoxy-5-methylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-Bromo-5-methylphenol | HCID 12648409 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Bromo-3-methoxy-5-methylbenzene | HCID 10679554 | — |
反応手順
A mixture of 5-bromo-3-hydroxytoluene (93 g, 0.5 m) and sodium hydroxide (21 g, 0.5 m) in water (200 ml) is stirred at 10°, treated with dimethyl sulfate (63 g, 0.5 m) over 1 hour, refluxed for 2 hours and cooled. The mixture is diluted with water and extracted with ether. The ether extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxytoluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04659706 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-463fc7d5baf7455d841575c1a42c4d3c |
| 出典メモ | uspto-grants-1987_04 |