2-(Trifluoromethyl)aniline → 1,1-Bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene

HRID 542886

反応式

HRID 542886 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]([S:16]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])=[CH:12]OCC)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:26][C:27]([F:36])([F:35])[C:28]1[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=1[NH2:30]>CC(N(C)C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]([S:16]([C:19]2[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])=[CH:12][NH:30][C:29]2[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=2[C:27]([F:26])([F:35])[F:36])(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 69222-(Trifluoromethyl)anilineHCID 33713701-Chloro-4-({1-[(4-chlorophenyl)sulfonyl]-2-ethoxyvinyl}sulfonyl)benzene

生成物 1

HCID 202075091,1-Bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene収率 50.1%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A solution of 1,1-bis(4-chlorophenylsulphonyl)-2-ethoxyethene (1.26 g) and 2-(trifluoromethyl)aniline (0.48 g) in dimethylacetamide (20 ml) was heated at reflux for 2 hours, and then it was cooled and poured onto ice (50 g). The resulting white precipitate was filtered off, washed with water and recrystallised from ethanol, to give 1,1-bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene (0.8 g), m.p. 169°-171° C.

後処理

  1. temperatureat reflux for 2 hours
  2. temperatureit was cooled
  3. additionpoured onto ice (50 g)
  4. filtrationThe resulting white precipitate was filtered off
  5. washwashed with water
  6. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-603f45c2fba84f72880705f9baeb8a82
出典データセット
uspto-grants-1987_04
特許番号
US04659727

関連ノート

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