Ethyl cyanoacetate → HCID 54272862、化合物

HRID 542951

反応式

HRID 542951 の反応式
[NH2:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[O:12][CH3:13].[CH2:14]([O:16][C:17](=[O:21])[CH2:18][C:19]#[N:20])[CH3:15]>N1CCCCC1>[CH2:14]([O:16][C:17](=[O:21])[C:18]([C:19]#[N:20])=[CH:6][C:5]1[CH:8]=[C:9]([O:10][CH3:11])[C:2]([NH2:1])=[C:3]([O:12][CH3:13])[CH:4]=1)[CH3:15]

参加物

4

反応物 2

HCID 7764Ethyl cyanoacetateHCID 200429634-Amino-3,5-dimethoxybenzaldehyde

生成物 1

HCID 54272862HCID 54272862、化合物

試薬・触媒・溶媒 1

HCID 8082Piperidine触媒

実験手順

A mixture of 18.1 g. of 4-amino-3,5-dimethoxy-benzaldehyde, 11.3 g. of cyanoacetic acid ethyl ester and 3 drops of piperidine was heated at 120° C. for 1 hour in an open vessel, whereby the formed water evaporated. The residue was recrystallized from ethyl acetate/petroleum ether and there was obtained 4-amino-α-cyano-3,5-dimethoxy-cinnamic acid ethyl ester having a melting point of 134°-136° C.

後処理

  1. additionA mixture of 18.1 g
  2. customwhereby the formed water evaporated
  3. customThe residue was recrystallized from ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-f25a0d0cbacc46d3b4d3b5f860565648
出典データセット
uspto-grants-1987_04
特許番号
US04659818

関連ノート

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