Sodium borohydride → 4-(Ethylamino)-3,5-dimethoxy-alpha-[(methylsulfonyl)-methyl]-benzyl alcohol

HRID 542979ノート

反応式

HRID 542979 の反応式
[CH2:1]([NH:3][C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:6][C:5]=1[O:19][CH3:20])[CH3:2].[BH4-].[Na+]>O>[CH2:1]([NH:3][C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([CH:12]([OH:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:6][C:5]=1[O:19][CH3:20])[CH3:2]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 212809514'-(Ethylamino)-3',5'-dimethoxy-2-(methylsulfonyl)acetophenone

生成物 1

HCID 541331734-(Ethylamino)-3,5-dimethoxy-alpha-[(methylsulfonyl)-methyl]-benzyl alcohol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of 48 g. of 4'-(ethylamino)-3',5'-dimethoxy-2-(methylsulfonyl)acetophenone and 23.8 g. of sodium borohydride in 1 liter of alcohol was stirred at room temperature for 20 hours, resulting in a solution. After the addition of 1 liter of water, the alcohol was evaporated under vacuum. The crystals formed were removed by filtration with suction, washed with water and dried, whereby there was obtained 4-(ethylamino)-3,5-dimethoxy-α-[(methylsulfonyl)-methyl]-benzyl alcohol having a melting point of 121°-122° C.

後処理

  1. additionA suspension of 48 g
  2. customresulting in a solution
  3. customthe alcohol was evaporated under vacuum
  4. customThe crystals formed
  5. customwere removed by filtration with suction
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-84fb47f0ff084616a91d0e0fa28f761b
出典データセット
uspto-grants-1987_04
特許番号
US04659818

反応ノート

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