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MAGNESIUM SILICATE (synthetic) → benzyl 5-formyl-2(S)-phthalimidopentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | MAGNESIUM SILICATE (synthetic) | HCID 61680 | — |
| 反応物 | (S)-2-Phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester | HCID 13851095 | — |
| 反応物 | HCID 178418287 | HCID 178418287 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | benzyl 5-formyl-2(S)-phthalimidopentanoate | HCID 11003033 | 79.4% |
反応手順
Benzyl 6-hydroxy-2(S)-phthalimidohexanoate (4.0 g) was dissolved in CH2Cl2 and treated with pyridinium chlorochromate (3.64 g). The reaction mixture was stirred under nitrogen for 4 hours and then diluted with 160 ml of ether. The mixture was filtered through a celite pad and concentrated to give an oil. This oil was passed through a short florisil column with ether as eluent. Concentration and drying in vacuo yielded pure benzyl 5-formyl-2(S)-phthalimidopentanoate (3.16 g); [α]D25° =-18.6° (CH2Cl2, c=4.1); I.R. (neat): 2730 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04661479 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-47ba65c3ab854e17af128a09832991eb |
| 出典メモ | uspto-grants-1987_04 |