Sodium borohydride → HCID 13247648、化合物

HRID 543328ノート

反応式

HRID 543328 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)[OH:7])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 13247647HCID 13247647、化合物

生成物 1

HCID 13247648HCID 13247648、化合物収率 89%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of 4.8 g of 3-(4-chlorobenzoyl)-2-(1-imidazolyl)pyridine in 35 ml of ethanol and 5 ml of water is added 0.64 g of sodium borohydride. After the mixture is stirred at room temperature for an hour, the reaction mixture is poured into water and extracted with chloroform. The chloroform is distilled off and the residue is recrystallized from toluene to give 4.3 g of α-(4-chlorophenyl)-2-(1-imidazolyl)-3-pyridinemethanol as white crystals, melting at 133°-134° C.

後処理

  1. extractionextracted with chloroform
  2. distillationThe chloroform is distilled off
  3. customthe residue is recrystallized from toluene

出典と根拠

ORDレコード
ord-c1ee3f8b47da4c8783eacc8df334087e
出典データセット
uspto-grants-1987_04
特許番号
US04661603

反応ノート

読み込み中…