Dichloromethane → 5-tert-Butyl-2-methylbenzene-1-sulfonyl chloride

反応式

[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8](O)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Cl:12][S:13]([OH:16])(=O)=[O:14].[CH2:17](Cl)Cl>>[CH3:1][C:2]([C:5]1[CH:10]=[C:9]([S:13]([Cl:12])(=[O:16])=[O:14])[C:8]([CH3:17])=[CH:7][CH:6]=1)([CH3:4])[CH3:3]

参加物

反応物 3

HCID 6344Dichloromethane2 回

HCID 73934-tert-Butylphenol

HCID 24638Chlorosulfonic acid

生成物 1

HCID 51688795-tert-Butyl-2-methylbenzene-1-sulfonyl chloride

実験手順

12.3 g (0.075 mol) of 4-(1,1-dimethylethyl)phenol in 30 ml of methylene chloride are added dropwise, cooling in ice, to 16.5 ml of chlorosulfonic acid dissolved in 20 ml of methylene chloride. The mixture is stirred for 40 minutes and then poured onto ice-water. The organic phase is separated off, washed with water, dried with MgSO4 and evaporated. The product is recrystallized from toluene petroleum ether.